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Feline Clinical Trials

Clinical research trials are helping pave the way to new medications, procedures and therapies in specialties such as cardiology, oncology, behavior, dermatology and neurology, among others. Clinical trials listed below are currently enrolling feline patients. If you are interested in a study or want more information, please contact the trial conductor listed at each description.

Date(s): Recruitment ends Aug. 1
Name of study: “Cats with High Grade Gastrointestinal Lymphoma”
Trial conductor / institution: The North Carolina State University College of Veterinary Medicine
Description: Cats diagnosed with high-grade lymphoma isolated to the gastrointestinal region are being recruited for a study to examine the effects of abdominal radiation therapy following induction chemotherapy.
Contact info: julie_osborne@ncsu.edu 
Notes: The study offers medical treatments, diagnostic and other compensation for participation.

Posted April 15, 2008

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Name of study: “Evaluation of Associations Between Oral Disease and Kidney Health in Cats”
Date(s): Currently enrolling until December 2008 or until study quota is reached
Description of study: The hospital is recruiting client-owned cats to participate in a clinical study that determines the relationship between feline oral disease and kidney health. This trial is designed to investigate a possible association between systemic parameters that could have an impact on early kidney disease and that may resolve with appropriate treatment under anesthesia (professional dental scaling, periodontal therapy and extractions as needed). In the course of this study, blood and urine samples will be obtained before treatment, and sampling is repeated four weeks after treatment. There is no additional fee for participating in this study. The owner will be charged for anesthesia. Diagnostic blood work and urine tests will be free.
Trial conductor / institution: Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania
Contact info: Veterinary Clinical Investigation Center and the Ryan Veterinary Hospital Dental and Oral Surgery Dept., 215-573-6540, reiter@vet.upenn.edu, http://www.pennvcic.org/

Posted July 10, 2008

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Name of study: Radiosurgery Treatment for Cats with Pituitary Tumors: A Pilot Study
Recruitment start date: Immediate
Recruitment end date: Feb. 28, 2009
Description of study: Acromegaly and pituitary-dependent hyperadrenocorticism (PDH) are endocrine diseases of cats resulting from the presence of a tumor in the pituitary gland. Both disorders are important as they cause debilitating clinical disease, with relatively high mortality rates. The medical and surgical options for management of feline PDH and acromegaly are currently limited and associated with significant complications, and this may lead to under diagnosis of these disorders. Radiosurgery is a promising new treatment option for these patients, as it usually requires only one or two fractions of radiation and anesthesia. The objectives of this study are to establish an efficacious treatment protocol for pituitary ablation by radiosurgery, to determine if there is resolution of endocrine disease after radiosurgery in cats with pituitary tumors, and to determine the effects of radiosurgery on pituitary function. Cats that have a pituitary tumor identified by computed tomography or magnetic resonance imaging, together with signs of endocrine disease, will be enrolled in the study. Patients will receive radiosurgery, with endocrine testing, clinical evaluation, and computed tomography before and after therapy. Patients should be referred to CSU for evaluation and radiosurgery. Client incentives are available.
Trial conductor / institution: Dr. Katharine Lunn, Department of Clinical Sciences, Colorado State University
Contact info: kathy.lunn@colostate.edu
Notes: Funding comes from Colorado State University.

Posted July 10, 2008

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Name of study: Effect of Fish Oil Supplementation in Feline Chronic Renal Failure
Recruitment start date: Immediate
Recruitment end date: June 30, 2009
Description of study: This is a randomized prospective placebo-controlled cross-over study, evaluating the effects of dietary fish oil supplementation on cats with chronic renal failure (CRF). Studies in dogs have suggested that fish oil supplementation may have several beneficial effects in animals with CRF. The researchers are particularly interested in effects on body weight, proteinuria, serum albumin and creatinine and markers of inflammation in the blood. In order to enroll in the study, cats must meet certain entry criteria, and the clients must consent to follow-up testing, which is provided at no charge. Because several veterinary prescription diets for feline CRF are supplemented with fish oil, this study is open to cats that refuse to eat prescription renal diets. The cats should have stable chronic kidney disease, in stage 2 or 3. All cats will receive both fish oil and placebo in a cross-over design. The total duration of the study is 19 weeks. Fish-oil or placebo, and follow-up laboratory testing are provided at no cost, and additional financial incentives are available.
Trial conductor / institution: Dr. Katharine Lunn, Department of Clinical Sciences, Colorado State University
Contact info: kathy.lunn@colostate.edu
Notes: Funding is through the Agricultural Experiment Station.

Posted July 10, 2008

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Name of study: Phase II study of Oral Docetaxel and Cyclosporine in Feline Epithelial Cancer.
Recruitment start date: Nov. 2, 2007
Recruitment end date: Oct. 31, 2009
Description of study: The study is funded by the Morris Animal Foundation and covers the cost of two doses of oral docetaxel which are given two weeks apart and the associated recheck blood work and examinations. This is a chemotherapy drug trial to determine the efficacy of oral docetaxel in the treatment of cats that have measurable epithelial tumors (including oral squamous cell carcinoma, nasal carcinoma, lung tumors, mammary gland adenocarcinoma, etc.).  A previous study has been completed to determine the appropriate dose of oral docetaxel in cats which is the dose being used in the current study.
Trial conductor / institution: Dr. Margaret C. McEntee, Cornell University
Contact info: Appointments can be made directly with the oncology service at the Cornell University Hospital for Animals by calling 607-253-3060.
Notes: Questions regarding eligibility into the study can be directed to Dr. McEntee, mcm43@cornell.edu.

Posted July 10, 2008

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Name of study: Cytauxzoon Felis Treatment Comparison
Recruitment start date: Immediately
Recruitment end date: June 30, 2011
Description of study: The study will evaluate two potential treatments for cytauxzoonosis in cats. Treatment will involve the administration of one of two drugs effective against some other types of protozoal germs, along with administration of intensive supportive care (intravenous fluids, transfusion, supportive medications). These drugs may have some benefit in treating cats infected with the protozoal organism that causes feline cytauxzoonosis but we do not know how effective these treatments will be. 
As with any new therapy that may or may not work, the ability of these drugs to improve the treatment outcome for infected cats must be judged fairly before it is recommended for treatment of all infected cats. This requires that these drugs be compared to each other to see which (if either) will be most effective. The study will compare cats treated with the best and most aggressive supportive care possible, plus either one of the two anti-protozoal drug regimens.

Inclusion criterion for the study include: clinical presentation compatible with cytauxzoonosis, cytologic demonstration of suspected C. felis piroplasms or schizonts, informed owner consent.

Cats which fulfill the three requirements for study inclusion are eligible for enrollment.  In an attempt to achieve meaningful results, certain historical, physical, and laboratory information should be collected from all enrolled cats. Additionally, while therapy is largely at the discretion of the treating veterinarian, certain aspects of care must be standardized and all therapeutic treatments should be recorded.

All cats will be provided supportive care and will be randomized to either one of two specific therapies in addition to standardized care: Imidocarb dipropionate or Atovaquone and azithromycin.

Supportive care will be provided all cats. These aspects of supportive care should be administered to all cats Intravenous crystalloid fluid therapy (LRS, normosol, or normal saline are each acceptable). Dose will be left to the discretion of the treating veterinarian but should likely be from 50-100 ml/kg/day. Unfractionated heparin should be administered at 200 U/kg SQ q 8 hours. 
Additional supportive care may include transfusion of whole blood or packed RBC, electrolyte supplementation, or nutritional support at the discretion of the attending veterinarian.

Benefits of the study: free PCR testing, free treatment study drugs, re-imbursement of up to $1,875.00 per case for care (pending finalization of funding), consultation with Dr. Cohn and/or Birkenheuer regarding case management. We are recruiting hospitals that see three or more C. felis cases per year.
Trial conductor / institution: Dr. Leah Cohn (University of Missouri), Dr. Adam Birkenheuer (North Carolina State University)
Contact info: Leah Cohn, DVM, PhD, Dipl. ACVIM, 573-882-7821, cohnl@missouri.edu; Adam Birkenheuer, DVM, PhD, Dipl. ACVIM, 919-513-8288, ajbirken@ncsu.edu

 Posted July 10, 2008

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Name of study: Secondary Prevention of Feline Cardiogenic Arterial Thromboembolization; Clopidorgrel vs. Aspirin Trial: The FAT CAT Study
Recruitment start date: 3/1/2006
Recruitment end date: Ongoing
Description of study: The study is the first prospective, double-blinded study evaluating the effect of antithrombotic therapy on the recurrence rate of cardiogenic embolism (arterial thromboembolism or saddle thrombus) in cats. The study is comparing the 1 year recurrence rate of cardiogenic embolism in cats receiving either aspirin or Plavix (clopidogrel). Additional data to be evaluated includes adverse effects of either study drug and overall survival.
Trial conductor / institution: Daniel F. Hogan, Purdue University, School of Veterinary Medicine
Contact info: 765-496-6743, fax 765-496-1025, hogandf@purdue.edu, www.vin.com/fatcat
Notes: The study is enrolling cats from all over the world and utilizes a web-based study interface funded by the VIN Foundation. The study does provide supportive funding to the owners which may assist with medical management of their pets. Cats are enrolled 1-3 months after suffering a clot event. This study is being funded by the Morris Animal Foundation.

Posted July 10, 2008

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Name of study: “Feline Chronic Renal Failure Study”
Date(s): Ongoing
Description of study: The college is recruiting cats with stable chronic renal failure for a clinical trial involving a new medication licensed for the treatment of renal secondary hyperparathyroidism in humans.
Trial Conductor / institution:  Dr. Melissa Riensche; University of Illinois College of Veterinary Medicine
Contact Info: 217-244-8321, riensche@uiuc.edu
Notes: Owners must be able to give the cat oral medication. All medical expenses associated with the study will be paid for.

Posted July 10, 2008

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