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Unintentional Exposure to Evamist May Have Adverse Effects in Pets, FDA Says

Pets that have inadvertent exposure to the human topical estrogen product, Evamist, may experience adverse effects, according to the U.S. Food and Drug Administration.

Evamist contains estradiol, an estrogen hormone, and is used in women to reduce hot flashes during menopause. The drug is sprayed on the skin between the elbow and wrist, on the inside of the forearm.

Since 2007, when Evamist was FDA approved, the FDA’s Center for Veterinary Medicine has received two reports of secondary exposure to the product in dogs. Pets exposed to Evamist may exhibit signs such as mammary/nipple enlargement and vulvar swelling, according to the FDA.

The FDA is warning pet owners that animals should not be allowed to lick or touch the arm where Evamist is sprayed. If direct contact cannot be avoided, the FDA recommends that women wear a garment that covers the area where the drug was applied.

The product should also be kept away from children, according to the FDA. From July 2007 to June 2010, the FDA received eight post-marketing cases of unintended exposure to Evamist in children ages 3 years to 5 years. Adverse events reported in unintentionally exposed children include premature puberty, nipple swelling and breast development in females, and breast enlargement in males.

The FDA noted that it is currently unknown if unintended exposure can occur with other topical estrogen products. The FDA said it is continuing to review adverse event reports and evaluate ways to reduce unintended exposures to these products.

The FDA is asking consumers and health care professionals to report any side effects from Evamist by using the FDA’s MedWatch Adverse Event Reporting program: call 800-332-1088 or visit www.fda.gov/medwatch. <HOME>

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Unintentional Exposure to Evamist May Have Adverse Effects in Pets, FDA Says

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Yes, it's true! My small male dog has an estrogen level that is off the charts! He has enlarged nipples, a giant penis and a UTI infection, including prostate infections. They are calling it a super bug and he is undergoing treatment with meds. In the meantime, I am not to have contact with him. That is not easy. Jenneen, Rancho Cucamonga, CA Posted: 9/12/2011 4:05:41 PM Hello, I was listening to the radio and heard about evamist causing nipple enlargement in pets, now it all makes sense, I started evamist about 3 mos. ago and started to notice that both my Jack Russell dogs had enlarged nipples, a female and male, I thought it was the food. I never have seen nipples on my male dog before and now there are big all 8 of them. I'm thinkin they get in contact with the mist when I spray it on my arms in the morining, or when I hold them. Barbara, Grass Valley, CA Posted: 8/1/2010 7:44:57 AM