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Glucosamine: Some Value, Little Risk

Posted: February 14, 2011, 3:25 p.m., EDT

By Narda Robinson, DO, DVM

FOOTNOTES

1. Wandel S, Juni P, Tendal B, et al. Effectcs of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip of knee: network meta-analysis. BMJ 2010;341:c4675. doi:10.1136/bmj.c4675.
2..Pelletier J-P et al. Effect size is encouraging. BMJ 2010;341:c6328.
3. Giacovelli G and Rovati LC. Conclusions not supported by methods and results. BMJ 2010;341:c6338.
4. Reginster J-Y, Altman RD, and Hochberg MC. Prescribed regimen is effective. BMJ 2010;341:c6335.
5. Block JA, Oegema TR, Sandy JD, et al. Review. The effects of oral glucosamine on joint health: is a change in research approach needed? Osteoarthritis and Cartilage. 2010;18:5-11.
6. McKenzie BA. What is the evidence? JAVMA. 2010;237(12):1382-1383.
7. Meulyzer M, Vachon P, Beaudry F, et al. Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride. Osteoarthritis and Cartilage. 2009;17:228-234.
8. Meulyzer M, Vachon P, Beaudry F, et al. Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride. Osteoarthritis and Cartilage. 2008;16:973-979.
9. Meulyzer M, Vachon P, Beaudry F, et al. Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride. Osteoarthritis and Cartilage. 2008;16:973-979.
10. Budsberg SC and Bartges JW. Nutrition and osteoarthritis in dogs: does it help? Vet Clin Small Anim. 2006;36:1307-1323.
11.Naito K, Watari T, Furuhata A, et al. Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model. Life Sciences. 2010;86:538-543.
12. Naito K, Watari T, Furuhata A, et al. Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model. Life Sciences. 2010;86:538-543.
13. Meulyzer M, Vachon P, Beaudry F, et al. Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride. Osteoarthritis and Cartilage. 2009;17:228-234.
14. Block JA, Oegema TR, Sandy JD, et al. Review. The effects of oral glucosamine on joint health: is a change in research approach needed? Osteoarthritis and Cartilage. 2010;18:5-11.
15. McCarthy G, O’Donovan J, Jones B, et al. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. 2007;174:54-61.
16. Lascelles BDX, DePuy V, Thomson A, et al. Evaluation of a therapeutic diet for feline degenerative joint disease. J Vet Intern Med. 2010;24:487-495. 17. Buse MG. Hexosamines, insulin resistance and the complications of diabetes: current status. Am J Physiol Endocrinol Metab. 2006;290(1):E1-E8.
18.Lenox CE and Lunn KF. Effects of glucosamine-chondroitin sulfate supplementation on serum fructosamine concentration in healthy dogs. JAVMA. 2010;236;183-186.
19. Lenox CE and Lunn KF. Effects of glucosamine-chondroitin sulfate supplementation on serum fructosamine concentration in healthy dogs. JAVMA. 2010;236;183-186.
20. Barrientos C, Racotta R, and Quevedo L. Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats. Nutrition Research. 2010;30:791-800.
21. Oke S, Aghazadeh-Habashi A, Weese JS, et al. Evaluation of glucosamine levels in commercial equine oral supplements for joints. Equine Veterinary Journal. 2006;38(1):93-95. 22 So J-S, et al, Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis, Life Sci (2010), doi:10.1016/j.lfs.2010.12.013.

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