20-plus clinics to participate in expanded osteosarcoma vaccine clinical trial

September 6, 2018

Initial results of a pilot study for canine osteosarcoma vaccine are promising, prompting a larger study to test its safety and efficacy.

Pharmaceutical company Aratana Therapeutics, which received conditional licensure for Live Listeria Vector (AT-014), has expanded its clinical trial to include more than two dozen veterinary oncology practice groups across the U.S. in order to receive full licensure. Conducted by the University of Pennsylvania School of Veterinary Medicine, the pilot study tested the immunotherapy treatment in 18 dogs. Those that received the vaccine lived more than twice as long as the historical, matched control group, with median survival times of 956 days compared to 423 days.

The expanded clinical trial is designed to collect additional safety data for the vaccine in dogs that have undergone amputation of the affected limb and have already completed chemotherapy.

If the treatment is found to be as safe and effective as it appeared in the initial clinical trial, Aratana will be given full licensure, allowing it to make the drug commercially available.

Live Listeria Vector (AT-014) is created by removing harmful genes from the Listeria bacteria and then attaching markers of osteosarcoma cells. It is designed to supplement standard osteosarcoma treatment of amputation and chemotherapy by attacking cancer cells that have spread to other organs.

The following clinics are participating in the expanded trial:

Click here[1] for a short video on the vaccine by Nicola Mason, PhD, BVetMed, associate professor of medicine at the University of Pennsylvania School of Veterinary Medicine. Dr. Mason helped develop the vaccine.

Endnotes:
  1. here: https://www.youtube.com/watch?v=qb0AX-nG0nM&feature=youtu.be

Source URL: https://www.veterinarypracticenews.com/20-plus-clinics-to-participate-in-expanded-osteosarcoma-vaccine-clinical-trial/