Improving the outlook for brain tumor patients

Is comparing tumor biology in dogs and people the key to a successful treatment for both species?

Golden retriever Holleigh recently participated in a clinical trial conducted through the Comparative Brain Tumor Consortium exploring an oral blood-brain barrier penetrant—procaspase-3 activator (PAC-1)—in combination with hydroxyurea for treatment of canine meningioma. She is pictured here with her owners, Travis and Casie Smith.

The path to discover and perfect new cancer treatments is long and expensive. It can take more than a decade and cost over $2 billion to demonstrate the safety and efficacy of a new therapeutic before it reaches the marketplace. To expedite the process, researchers are thinking outside the box—or rather, outside their own species. The concept of comparative medicine (i.e. One Medicine) has great potential to a...


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