Is immunotherapy the key to wiping out canine cancer?

How adoptive cell therapy with autologous CAR-T cells may offer durable clinical remissions

An intact and functional immune system is essential to protect an organism against invading pathogens and infectious disease. However, the immune system also plays a pivotal role in identifying and eliminating transformed cells that, if left unchecked, would progress to cancer.

Clinical evidence of the immune system’s ability to control cancer comes from a number of observations in both the veterinary and medical settings. Consider the following examples:

Cats receiving chronic immunosuppression following renal transplant have a higher incidence of lymphoma compared with the general feline population1,2
Spontaneous regression of transmissible venereal tumor is associated with an increased proportion of tumor-infiltrating cytotoxi...


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