Questions about anti-nerve growth factor drugs

An evidence-based veterinary medicine approach to new offerings.

The manufacturer of a feline-specific, monoclonal antibody (mAB) drug now awaits approval for its canine counterpart. Photo: TatyanaGl/Bigstock

Earlier this year, veterinarians in the United States finally gained access to a synthetic, feline-specific, monoclonal antibody (mAB) drug designed to treat osteoarthritis pain in cats. Administered as a once-monthly injection, frunevetmab binds to a neurotrophin called nerve growth factor (NGF), a protein found in heightened amounts in painful, arthritic joints.1 By keeping NGF from binding to its receptors, frunevetmab limits its ability to issue nociceptive signals to the spinal cord and brain.
For well over a decade, human pharmaceutical companies invested billions of dollars into d...


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