The Bountiful Benefits Of Boswellia
Discover why the botanical medicine Boswellia is experiencing a resurgence and what it can do for your animal patients.
The popularity of boswellia, a botanical medicine discovered more than three millennia ago, is experiencing a resurgence.
Long recognized for its anti-inflammatory benefits, this oleogum resin also has anti-cancer and immunomodulatory properties.1 Boswellia, or frankincense, harkens back to ancient India and Egypt.
Frankincense was one of the four components in the medicinal "Balsam of Jerusalem" from the Franciscan Monastery2 and, as noted in the Papyrus Ebers, circa 1500 BCE, had applications in Egypt for mummification, cremation and the treatment of skin wounds.3,4
In the Indian medical system Ayurveda, boswellia goes by the term "salai guggul." Its Sanskrit name, Gajabhakshya, suggests that humans observed elephants ingesting the plant. That is, ancient Indian Ayurvedic healers witnessed these huge animals feeding on Boswellia serrata trees, which grow widely across the dry hills of northwest India.
Coupling this observation with their knowledge of elephants' longevity and astounding physical capacity, these early doctors began questioning whether the elephants' dietary intake of boswellia might offer similar benefits to humans, though in much smaller amounts.5
Boswellia, or boswellic acids, exhibit anti-inflammatory properties, demonstrated both in vitro and in vivo.
Triterpenes in boswellic acid reduce the synthesis of leukotrienes in intact neutrophils by inhibiting 5-lipoxygenase, the key enzyme involved in the biosynthesis of leukotrienes, which mediate inflammation. 6,7
Leukotrienes form via the lipoxygenase pathway, subsequent to the enzymatic oxidation of arachidonic acid. Certain inflammatory states, including colitis and bronchial asthma, are characterized by increased concentrations of leukotrienes.
Leukotrienes incite chemotaxis, chemokinesis, superoxide radical formation and phagocytic expulsion of lysosomal enzymes. 8 In cases of asthma, leukotrienes induce bronchoconstriction, increased mucus secretion and edema, and promote production of an eosinophil-rich inflammatory cellular infiltrate.9
In cases of intestinal inflammation, boswellic acids may modulate the adhesive interactions between leukocytes and endothelial cells, by countering the activation of leukocytes or down-regulating the expression of endothelial cell adhesion molecules.13,14
On the anti-cancer front, boswellic acids induce antiproliferation, differentiation and apoptosis in leukemia cell lines.15,16,17,18 They exert cytotoxic effects on established human glioblastoma and leukemia cell lines, as well as on primary human meningioma cells.19
New information reveals that an extract from a related species, Boswellia elongate, showed significant inhibitory activity against angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), and aminopeptidase N (APN).20 The zinc-endopeptidases NEP and ACE work their enzymatic activity on the outer surface of certain cells and participate in the metabolism of regulatory peptides such as substance P, bradykinin, natriuretic peptide, enkephalins and other hormonal and vasoactive peptides.
Boswellia extracts thus inhibit the renin-angiotensin-aldosterone system and stimulate the kinin system and natriuretic peptides, and, as a result, reduce vasoconstriction, increase vasodilation, and improve sodium-water balance.
Boswellia is perceived to be a safe and effective remedy for a number of conditions. In fact, Germans with inflammatory bowel disease (IBD) placed Boswellia serrata extract among the top three most beneficial CAM treatments by IBD patients in Germany, along with probiotics and acupuncture.21
In one study, the gum resin of Boswellia serrata provided improvements in patients with chronic colitis comparable or better than pharmaceutical treatment with sulfasalazine.22
Clinical studies have also shown boswellia to benefit patients with arthritis. An uncontrolled study on dogs with arthritis showed a significant reduction in the severity of clinical signs.23 A human study on patients with osteoarthritis of the knee showed that boswellia decreased pain and swelling and increased range of motion and endurance.24
For cancer patients, boswellic acids may help reduce cerebral edema in patients with brain tumors, helping reduce the need for steroids and their significant adverse side effects.25
The pharmacokinetics for most herbs given to veterinary patients continue to be a mystery. In humans, one study showed that the elimination half-life for boswellia was approximately six hours, suggesting that oral administration would require dosing every six to eight hours.26
The presence of food in the stomach, as well as the type of food eaten, dramatically alters the bioavailability of boswellic acids, and bile acids significantly affect their absorption.27
When human subjects ingested boswellic acids with a high-fat meal, the areas under the plasma concentration-time curves and peak concentrations totaled several times higher than when the herbal preparations are taken in the fasting condition.
Another study showed that combining certain boswellic acid extracts with ethanol produced significant cellular toxicity, which was not observed in a sesame oil preparation.28 This finding underscores the importance of pursuing further research in phytopharmaceuticals to ensure their safe administration.
Although veterinary patients are unlikely to imbibe ethanol voluntarily, they may encounter ethanol in other herbal extracts they are taking.
Frankincense extracts, as well as boswellic acids themselves, display moderate to potent inhibition of human drug-metabolizing cytochrome P450 enzymes,31 but the clinical significance and comparative effects on non-human P450 enzyme systems remain largely unexplored.
Dr. Robinson, DVM, DO, MS, Dipl. ABMA, FAAMA, is an assistant professor in complementary and alternative medicine in the department of clinical sciences at Colorado State University.
7. Roy S Khanna S, Krishnaraju AV et al. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to anti-inflammatory Boswellia. Antioxidants & Redox Signaling. 2006;8(3&4):653-660.
8. Roy S Khanna S, Krishnaraju AV et al. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to anti-inflammatory Boswellia. Antioxidants & Redox Signaling. 2006;8(3&4):653-660.
9. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res. 1998;3:511-514.
11. Roy S Khanna S, Krishnaraju AV et al. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to anti-inflammatory Boswellia. Antioxidants & Redox Signaling. 2006;8(3&4):653-660.
13. Krieglstein CE, Anthoni C, Rijcken EJM, et al. Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis. Int J Colorectal Dis. 2001;16:88-95.
14. Anthoni C, Laukoetter MG, Rijcken E, et al. Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1131-G1137.
17. Zhao W, Entschladen F, Liu H, et al. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detection and Prevention. 2003;27:67-75.
21. Joos SS, Rosemann TT, Szecsenyi JJ, et al. Use of complementary and alternative medicine in Germany – a survey of patients with inflammatory bowel disease. BMC Complementary and Alternative Medicine. 2006;6:19. In press.
24. Kimmatkar N, Thawani V, Hingorani L et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomized double-blind placebo controlled trial. Phytomedicine. 2003;10:3-7.
29. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res. 1998;3:511-514.
30. Kimmatkar N, Thawani V, Hingorani L et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomized double-blind placebo controlled trial. Phytomedicine. 2003;10:3-7.
31. Frank A and Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolizing cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. Journal of Chromatography A. 2006;1112:255-262.
<HOME>Posted: June 20, 2007By Narda Robinson, DVM5/23/2012 2:33 PM