Photo courtesy Dr. Kendra Freeman An 18-month-old female intact great Pyrenees presents for several weeks with a history of left hind limb lameness. 1) Which of the following is true about treating canine osteosarcoma? a) Oral medications for palliative care offer a median survival time (MST) of about three months. b) Full limb amputation offers an MST of approximately three to six months. c) Full limb amputation with chemotherapy offers an MST of six to 12 months. d) All of the above. e) None of the above. 2) Elevated serum alkaline phosphatase values are associated with a negative prognosis. a) True. The median disease-free interval (DFI) for dogs with elevated ALP was 170 days vs. 366 days for dogs without elevated ALP. b) False 3) Dogs weighing more than 40 kg have a better prognosis than smaller dogs. a) True b) False Reference Veterinary Society of Surgical Oncology. Accessed on Geb. 16, 2025 at http://vsso.org/bone-appendicular-osa.