Jaguar Optimistic About Diarrhea DrugOctober 30, 2015Jaguar Animal Health, which last year launched its initial gastrointestinal product, over-the-counter Neonorm Calf, expects to enter the prescription drug market in the first half of 2016. The San Francisco company has submitted data to the U.S. Food and Drug Administration in support of Canalevia, which would be used to treat chemotherapy-induced diarrhea in dogs. Jaguar is requesting MUMS (minor use in a major species) status. Also in the prescription pipeline is a formulation of Canalevia to treat acute diarrhea in dogs. A pivotal efficacy trial could begin by year’s end, and Jaguar hopes to file a New Animal Drug Application (NADA) in 2016. Both Canalevia versions contain the active ingredient crofelemer, a botanical extract of the Croton lechleri tree. Jaguar is investigating Canalevia formulations for cats and horses. The manufacture of enteric-coated crofelemer tablets would be done by Patheon Inc. of Durham, N.C., under a contract signed in mid-October. Patheon makes a similar product for human HIV patients suffering from noninfectious diarrhea. In other news announced this month, Jaguar: Signed a four-year supply agreement with India-based Glenmark Pharmaceuticals Ltd. for the production of crofelemer. Completed an additional field study of Neonorm Calf, an enteric-coated tablet administered …
SPONSORED CONTENTSupport patients' cognitive function and mobility.Cognitive and mobility decline are common issues facing aging pets, and new Hill's Prescription Diet Brain Care + j/d can help. + Learn More
N.Y. Hospital Opens Pet Cancer InstituteOctober 30, 2015New York’s Animal Medical Center, billed as the world’s largest small animal practice, this month added another claim to fame: a top-of-the-line oncology center. The 2,470-square-foot Cancer Institute fills the remodeled uppermost floor of the eight-story hospital on East 62nd Street in Manhattan. The uniting of the hospital’s oncology services was made possible through a $5 million gift from Animal Medical Center trustee Elaine Langone and her husband, Kenneth. “The core mission of the institute is to provide the highest quality of life for animals with cancer as well as to maximize the amount of time owners can spend with their beloved pets,” Elaine Langone said. “Having lost quite a few dogs to cancer, Ken and I believed the new Cancer Institute … was an initiative worth supporting.” Four board-certified oncologists staff the institute along with 18 other hospital employees. One of the doctors, Rachel St-Vincent, DVM, MVSc, Dipl. ACVR, is the state’s only onsite, full-time radiation oncologist, a hospital spokeswoman said. Animal Medical Center, which opened in 1910, employs about 100 veterinarians and sees 44,000 patients a year. The nonprofit hospital has long participated in pet cancer research. Collaboration between Animal Medical Center, Memorial Sloan Kettering Cancer Center and drug …
Vet Techs Say Sedation Is UnderutilizedOctober 27, 2015Being bitten, scratched or kicked by a patient is an accepted part of life at a veterinary hospital. But members of the National Association of Veterinary Technicians in America (NAVTA) believe the risk of injury would be reduced if more animals were sedated. A survey published in the October/November issue of The NAVTA Journal found that a veterinary technician is called upon to physically restrain a patient an average of 11 times a week and that sedation was used in less than half of the cases where it would have been appropriate. The American Animal Hospital Association’s “Anesthesia Guidelines for Dogs and Cats” states that sedation may be suitable during short, minimally invasive procedures such as diagnostics, joint injections, suture removal and wound management. More complex cases and treatments lasting more than 30 minutes may require anesthesia. The 1,262 NAVTA members who responded to the survey reported that sedation was used most often during exploration or repair of wounds or cuts, during euthanasia and when an animal had a troublesome temperament. Other top cases that called for sedation were during radiology procedures, fracture stabilization and the removal of foreign objects. “Interestingly, you reported that procedure type has more influence on …
What You Need to Know About Cardiomyopathy in CatsOctober 12, 2015Originally published in the October 2015 issue of Veterinary Practice News. Enjoyed this article? Then subscribe today! One type of heart disease appears to be responsible for the lion’s share of cases seen in cats. “The vast majority of the cardiac disease we see in cats is due to some form of cardiomyopathy — primary heart muscle disease,” said Mark D. Kittleson, DVM, Ph.D., Dipl. ACVIM (cardiology), a professor emeritus at the UC Davis School of Veterinary Medicine. “Hypertrophic cardiomyopathy probably accounts for 60-70 percent of that.” Dr. Kittleson, who also works for the Veterinary Information Network, said HCM can be passed down from some cats to their offspring. “It’s known to be heritable in Maine coons and ragdolls, where causal mutations have been identified,” Kittleson said. “Many other breeds get HCM, but most of the HCM seen is in crossbred cats.” HCM is not present at birth. It develops over time and can show up as early as 6 months of age. However, it is often identified for the first time in a geriatric cat. Kittleson explained that the disease causes a thick left …
Onsior Now Comes in Injection FormOctober 9, 2015Elanco Animal Health has released an injectable formulation of Onsior for pain management in cats. Onsior (robenacoxib) tablets were launched in 2012 under Novartis Animal Health, which Elanco acquired earlier this year. The two formulations may be used interchangeably, Elanco reported this week. Onsior injection is indicated for 24-hour control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration. The drug may be used in cats at least 4 months old and weighing at least 5.5 pounds. Onsior injection “provides veterinarians with the flexibility to choose the administration formulation and corresponding labeled dose that best fit within their surgical protocols,” the Greenfield, Ind., company stated.
Why Diagnosing Pancreatitis in Dogs and Cats is Still a ChallengeAugust 19, 2015Originally published in the August 2015 issue of Veterinary Practice News. Loved this article? Then subscribe today! Pancreatic lipase immunoreactivity, or PLI, is the most accurate laboratory test for diagnosing pancreatitis in dogs and cats, experts say. Accurately identifying this gastrointestinal malady has long baffled practitioners. Pancreatic biopsy is considered the gold standard diagnostic test for pancreatitis, but it is uncommonly performed due to the invasiveness and expense of the surgery. Most clinical cases can be diagnosed with a combination of a compatible history and clinical signs, and with the serum PLI and abdominal ultrasound, said Steve Hill, DVM, MS, of Veterinary Specialty Hospital of San Diego. “Routine serum amylase and lipase levels, which are commonly part of general chemistry panels, have limited utility in diagnosing pancreatitis due to their low sensitivity and specificity in both dogs and cats,” said Dr. Hill, a diplomate of the American College of Veterinary Internal Medicine, small animal, and the immediate past president of the Comparative Gastroenterology Society. “The most accurate laboratory diagnostic test is the pancreatic lipase immunoreactivity, which measures pancreas-specific lipase and has very good sensitivity and specificity for acute and chronic pancreatitis,” he …
What You Need to Know About Murmurs and Heart Disease in Senior DogsAugust 12, 2015Originally published in the August 2015 issue of Veterinary Practice News. Subscribe today! A loud murmur may not indicate heart disease in a dog, and conversely, a dog with heart disease may not necessarily have a loud heart murmur. That was the top piece of advice to general practitioners offered up by Pamela M. Lee, DVM, Dipl. ACVIM (Cardiology), an assistant professor in veterinary clinical sciences at Washington State University College of Veterinary Medicine. In older, small- to medium-size breed dogs, the most common heart diseases are degenerative issues, such as endocardiosis, also called chronic degenerative-valve disease or acquired valvular heart disease, Dr. Lee said. For large-breed dogs, the most common heart disease is dilated cardiomyopathy, where heart muscle contracts poorly, Lee said. When checking for endocardiosis, it’s the type of heart murmur, not the loudness, that a practitioner should listen for. “One of the big things to know, at least with endocardiosis: The severity of the heart disease does not correlate with a loud heart murmur,” Lee said. This may be important to keep in mind, because experts spoken with, including Lee, pointed to …
Do Dogs and Cats Get Cavities?June 8, 2015Originally published in the June 2015 issue of Veterinary Practice News Dental caries (the medical term for cavities caused by tooth decay) are common in people but rare in our veterinary patients. Dental caries were first described in domesticated dogs in 1962.1 The NIH reports that 92 percent of adult humans between the age of 20 and 64 have cavities of their permanent teeth. The prevalence of caries in dogs is low, having been documented at 5 percent in a study of 435 dogs.2 Caries in cats are very rare (almost nonexistent). Etiology What’s the difference between caries and the more commonly seen veterinary problem of tooth resorption? The etiology of caries is due to a combination of having the right bacteria in the mouth (usually a bug called Streptococcus mutans) and having carbohydrate substrates for S. mutans to form acids that eat away at the surface of a tooth. Often times, even that is not enough to cause cavities. Often there is a genetic predilection of a developmental abnormality of a tooth to allow the enamel to be penetrated by these acids. The most common type of caries lesions is referred to as “pit-and-fissure” caries, which most commonly occurs …
UC Davis Gives Cat New EyelidsMay 15, 2015Practice made perfect for UC Davis veterinary ophthalmologists, who after performing a rare transplant on feline cadavers were able to construct upper eyelids on a cat born without them. The surgery, called lip commissure to eyelid transposition, was successfully performed on a 9-month-old female domestic shorthair named Billie, who suffered from a congenital defect known as eyelid agenesis. The condition was a source of constant discomfort as hair around Billie’s eyes rubbed against the corneas, according to the University of California, Davis, School of Veterinary Medicine. The absence of eyelids also prevented Billie from blinking and lubricating her eyes. A surgery team made up of Ophthalmology Service veterinarians Ann Strom, DVM, MS, and Lionel Sebbag, DVM, knew about a procedure never tried before at UC Davis but documented in the journal Veterinary Ophthalmology in 2010. Drs. Strom and Sebbag practiced removing tissue from the cadavers’ cheeks and lips and transplanting it as an eyelid, the university stated. Once confident in their ability, the surgeons consulted with Billie’s owner, who gave the go-ahead for the transplant. Billie’s tissue grafts showed no signs of rejection or infection at one- and two-week checkups. After two months, the new eyelids were taking …
Blue Buffalo Faults Supplier for Wide Use of Byproduct MealMay 12, 2015Blue Buffalo Co., one of the world’s largest pet food makers, admitted in a courtroom May 6 that a substantial portion of its products at one time contained poultry byproduct meal, and the company blamed the situation on a supplier’s “mislabeling scheme.” The acknowledgment came as the Wilton, Conn., manufacturer asked a U.S. District Court judge in St. Louis to interrupt proceedings in a lawsuit filed by competitor Nestlé Purina PetCare Co. The judge granted a three-month delay to give Blue Buffalo time to sue Wilbur-Ellis Co. and draw the San Francisco animal feed supplier further into the case. Blue Buffalo and Purina have engaged in a long-running war of words and legal fight over allegations that some Blue Buffalo food was made with poultry byproduct meal contrary to the company’s labeling and advertising. A countersuit filed by Blue Buffalo accuses Purina, the world’s No. 2 pet food manufacturer, of defamation, unfair competition and false advertising. Both companies verbally attacked each other in the days after the court hearing. “Despite this admission, Blue Buffalo still has not informed consumers of the presence of poultry byproduct meal in Blue Buffalo pet food, refuses to accept responsibility for the product it …
