Differential Diagnosis Of Hypercalcemia

Hypercalcemia is defined as a total serum calcium concentration of more than 11 mg/dl in a cat and more than 12 mg/dl in a dog.

Hypercalcemia is defined as a total serum calcium concentration greater than 11 mg/dl in the cat and 12 mg/dl in the dog. Hypercalcemia can have many etiologies. It is important to be very thorough when investigating the cause.

Differential diagnosis of hypercalcemia includes:

• Lymphoma
• Anal sac apocrine gland adenocarcinoma
• Multiple myeloma
• Lymphocytic leukemia
• Various carcinomas
• Metastatic bone tumors
• Addison’s disease
• Primary hyperparathyroidism
• Acute or chronic renal failure
• Granulomatous diseases
• Vitamin D toxicosis
• Osteomyelitis (bacterial or fungal)
• Juvenile patient
• Sampling error (lipemia, hemolysis)
• Lab error


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