Kindred Unsuccessful With First Canine DrugAugust 21, 2014 Kindred Biosciences Inc. has been dealt a setback with the discovery that the startup drug company’s vanguard product, CereKin, failed a pivotal field study. The Burlingame, Calif., company had hoped to achieve U.S. Food and Drug Administration approval of CereKin (diacerein) for the control of osteoarthritic pain and inflammation in dogs sometime in 2015. Kindred reported Wednesday that CereKin “did not meet its primary endpoint.” The randomized, double-blind, placebo-controlled study evaluated the safety and efficacy of two doses of CereKin (5 mg/kg and 20 mg/kg). “The data are in the process of being fully analyzed but, based on the analyses so far, the results appear to be due primarily to a higher-than-expected placebo response rate and statistical variability,” Kindred stated. “Also, in the high-dose group, the response rate among completers was in line with results seen in human studies, but the dropout rate was higher than expected and statistical significance was not achieved for the primary endpoint.” Kindred spent about $4 million on the development of CereKin—a sum in line with what the drug maker anticipates spending on each project. Still in the pivotal study stage are AtoKin (fexofenadine), which is designed …
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The Pet Industry Agrees: More Pet Insurance Regulation in California Is a Good ThingAugust 21, 2014 #182175130 / gettyimages.com Update: Dababneh Assembly Bill 2056, as of August 20, 2014, has passed both the California Senate and Assembly. Originally published in the August 2014 issue of Veterinary Practice News. California’s insurance regulator and a state lawmaker want to step up oversight of the pet insurance industry—and the majority of the pet insurance industry is behind them. California Insurance Commissioner Dave Jones and Assemblyman Matt Dababneh, D-Encino, are rapidly pushing through the legislature Dababneh’s Assembly Bill 2056, which the men say will add consumer protections to pet insurance by bringing uniformity to policy language and disclosures to increase transparency in pet insurance policies. “California has the largest number of insured dogs and cats in the nation,” Jones said. “It is essential that consumers purchasing pet insurance understand what they’re getting for their money. When policy terms are more easily understood, consumers are better able to select a product that meets their needs.” Jones said the bill would provide important consumer protections now absent from pet insurance. For the most part the pet insurance industry is …
Purina to Offer Brain Supplement in Some FoodsAugust 20, 2014 A nutritional supplement formulated to support the brain functions of middle-aged cats and dogs will be added to selected Nestlé Purina products within 12 to 18 months, the pet food manufacturer reported Monday. The supplement, called Brain Protection Blend, targets risk factors linked to brain aging. Containing fish oil, antioxidants and an amino acid known as arginine, it is designed to be fed when a pet is middle-aged. A Nestlé Purina study of how Brain Protection Blend benefits dogs will be published in coming weeks, the company stated. Nearly 30 percent of cats aged 11 to 14 show signs of cognitive decline, including memory loss and reduced social interaction, Nestlé Purina noted. Among dogs, 28 percent of 11- and 12-year-olds and 68 percent of 15- and 16-year-olds show at least one sign of cognitive issues. “By taking a more proactive approach, we may be able to slow the brain’s decline often experienced among pets as they get older,” said Dan Smith, Nestlé Purina’s vice president of research and development. Nestlé Purina, whose U.S. pet division is based in St. Louis, won’t be the first company to offer a proprietary pet food enhancer. For …
Virgina-Maryland Opens Around-the-Clock Skills LabAugust 20, 2014 It’s 3 a.m. and you can’t sleep. What can you do? Students enrolled in the Virginia-Maryland College of Veterinary Medicine can practice bandaging, catheterization, intubation and suturing inside a new lab that is open 24/7. The clinical skills lab is stocked with animal models and mannequins, allowing veterinary students such as Anna Katogiritis to become more proficient at what they likely will be doing after graduation. “The models have veinlike tubes in their legs that really allow you to perform techniques as if you were practicing on a real animal,” said Katogiritis, a second-year student from Karpathos, Greece. “At the same time, knowing that I was not putting a live animal at risk or distress eliminates the stress factor and allowed me to focus on the techniques themselves.” Veterinarians and veterinary technicians manage the Blacksburg, Va., lab but are not scheduled around the clock. During off hours, students can walk in and practice on their own. “When the lab is staffed, students can receive instruction and immediate feedback on their skills,” said Meghan Byrnes, DVM, an instructor in the department of small animal clinical sciences. “In addition, the lab is always open for …
CSU Studies Effects of Climate Change in Polar BearsAugust 19, 2014 Colorado State University is helping lead a research project that seeks to better understand the impacts of climate change and infectious disease in polar bear populations. Polar bears, as the university describes it, have become a poster species for climate change because the animals have always lived by hunting seals on remote ice. With the melting sea ice, polar bears increasingly are moving inland. This shift has the potential to spawn a “perfect storm” that could devastate polar bears through decreased food supply and increased exposure to disease, pollution and people, according to Colleen Duncan, DVM, assistant professor of pathology at CSU College of Veterinary Medicine and Biomedical Sciences and a lead investigator of the project. Colorado State University Dr. Colleen Duncan, a veterinary pathologist at CSU, studies disease and population dynamics in Arctic wildlife. For example, polar bears have joined the scavengers that feed on whale bones piled together by indigenous Alaskan tribes, Dr. Duncan said. This relatively new behavior means different food, disease and environmental exposure that could affect bear health in multiple ways, she noted. Just this spring, Duncan traveled to northernmost Alaska with fellow researchers from …
AVMA Economic Meeting Set for Oct. 28August 19, 2014 Registration is underway for the American Veterinary Medical Association’s second annual Economic Summit, which will explore topics such as what veterinarians are earning and why more practices are consolidating. The all-day meeting will take place Oct. 28 at the Westin O’Hare in suburban Chicago. Among the speakers will be Michael Dicks, MS, Ph.D., the AVMA’s director of veterinary economics; Jeffrey Klausner, DVM, MS, Dipl. ACVIM, the chief medical officer at Banfield Pet Hospital; and Lisa Greenhill, the associate executive director for institutional research and diversity at the Association of American Veterinary Medical Colleges. Veterinary compensation, veterinarian supply and demand, the prices charged for veterinary services, and how veterinary markets influence everyday business decisions will be discussed. The registration cost is $199 until Oct. 6 and $249 afterward. More information is available at AVMA.org/Events/Symposiums.
U.S. Cracks Down on Sale of Foreign PuppiesAugust 19, 2014 The federal government has imposed new restrictions on the importation of puppies under 6 months old, drawing praise from the American Kennel Club and the American Society for the Prevention of Cruelty to Animals. The rule, part of an amendment to the Animal Welfare Act, prohibits young puppies from entering the continental United States for resale, research or veterinary purposes. Puppies under 6 months old will be permitted if they are a personal pet, breeding stock, or a show, competition or training dog. The regulations were published Monday in the Federal Register and go into effect Nov. 17, 2014. “We welcome this new rule as it will reduce the suffering of thousands of animals by curbing the importation of sick puppies from overseas,” said Cori Menkin, senior director of the ASPCA Puppy Mills Campaign. “Breeding facilities in foreign countries are not subject to oversight by the United States government, so the conditions under which many of these dogs are bred and raised are substandard. The new rule means that the U.S. no longer provides a friendly marketplace for these suffering animals.” The AKC, which registers purebred dogs and sanctions events, stated that it was “pleased.” …
British Vets Forced to Compete With ‘Dr. Google’August 18, 2014 British practitioners are fed up with the world’s most popular veterinarian, who they accuse of encouraging clients to self-diagnose and treat their pets at home, sometimes to the detriment of the animal. The veterinarian, known only as “Dr. Google,” has influenced the vast majority of pet owners, according to the British Veterinary Association. The veterinary organization reported Sunday that 98 percent of practitioners surveyed stated that their clients’ behavior was swayed by what the pet owners found online. Furthermore, nearly 40 percent of veterinarians said the owners’ online research was unhelpful. “It worries me to hear that so many people are relying on guesswork or unverified Internet sources for health advice for their pets,” said BVA President Robin Hargreaves, MRCVS. “While there is some useful information about pet behavior and health available online, particularly from the established animal charities, the best source of information for animal health concerns will always be your vet, who knows your pet.” Across the Atlantic, Dr. Google has been blamed for lackluster interest in regular veterinary checkups. A 2014 survey conducted by the coalition Partners for Healthy Pets found that 48 percent of U.S. pet owners first turned to the …
Purdue to Develop Standards for Dog BreedersAugust 15, 2014 Commercial dog breeders nationwide may adhere to the same animal care standards in a few years if a Purdue University project is successful. Candace Croney, MS, Ph.D., an associate professor of comparative pathobiology and animal science, is embarking on a two-year research assignment designed to develop and test science-based best practices covering everything from the housing of breeding dogs to their health. “Although many states have standards in place, they are highly variable from state to state,” Croney said. “In addition, several factors that significantly impact dog welfare, such as their housing, have not been well studied, raising questions about the basis and adequacy of current standards. “This project will help fill the gaps in regard to better meeting dogs’ needs,” she said. The work is underwritten by the Pet Industry Joint Advisory Council, the Pet Food Institute and the World Pet Association. Other Purdue researchers and institutions such as the U.S. Department of Agriculture’s Center for Animal Welfare will participate. Dog breeders have come under fire for the conditions that some animals and their offspring are exposed to. Some jurisdictions ban the retail sale of commercially bred dogs. “Given that over …
Virus Hits Livestock Hard in Colorado, TexasAugust 15, 2014 Vesicular stomatitis, a contagious but rarely fatal livestock disease, has been diagnosed at nearly 190 locations across Colorado and Texas since the viral outbreak began in late May. The U.S. Department of Agriculture reported Wednesday that 76 new premises, or locations, have been identified since Aug. 6. The new cases involved 105 horses, five head of cattle and three previously disease-free counties. Two of the newly infected counties, Broomfield and Jefferson, are in Colorado, while the other is Williamson County, Texas. “Veterinarians have been very observant and diligent to report horses and other livestock that are suspicious of being infected,” said the Colorado state veterinarian, Keith Roehr, DVM. Livestock owners outside of Colorado and Texas should take precautions, said Elizabeth Davis, DVM, Ph.D., Dipl. ACVIM, a director of equine medicine and surgery at Kansas State University. “It’s an interesting disease because it does have pretty significant clinical signs,” Dr. Davis said. “Most commonly, it causes painful oral blisters in horses that can affect the mouth, muzzle and tongue. Additional signs may include lesions on the udder and/or around the top of the hoof where it meets the hairline. “Vesicular stomatitis also …
