Purdue University research aims to customize cancer treatmentsApril 26, 2018Researchers at Purdue University exploring Doppler light scattering, a new method for testing how patients will respond to various drugs, say it could help customize chemotherapy treatments for patients diagnosed with cancer, paving the way for more effective, personalized treatments. Similar to meteorological Doppler weather radar, which sends electromagnetic waves into clouds to determine the overall motion of raindrops, Doppler light scattering creates a 3-D map of activity occurring within living tissue samples, allowing researchers to see how cancerous cells respond to different chemotherapy drugs and treatment methods. "We're looking at the motion inside living tissue rather than rain droplets, and we're using infrared light instead of radar," said David Nolte, Ph.D, professor of physics and astronomy at Purdue. "It's like watching the weather inside living tissue as the tissue is affected by cancer drugs." Working in collaboration with John Turek, Ph.D, professor of basic medical sciences at Purdue's College of Veterinary Medicine, and Mike Childress, DVM, associate professor of veterinary medicine, Nolte's team performed the study on 19 dogs previously diagnosed with B-cell lymphoma, which is molecularly and clinically similar to lymphoma in humans. To test the Doppler light scattering method, biopsied tissue samples were placed in a multi-wall …
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