Study explores predicting canine disease risk through genetic testingJune 21, 2018 Genetic testing can be used to predict if a dog is at risk for developing certain diseases, enabling preventative care for better health, reports a new study by Wisdom Health and Genoscoper Laboratories. Published in PLOS Genetics, the study, "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs," also shows fewer mixed-breed dogs than purebreds are affected by the most common disease-causing mutations tested in the study. "There has been a long-standing perception that mixed-breed dogs are less disease prone than purebred dogs," said Cindy Cole DVM, Ph.D., DACVCP, general manager at Wisdom Health. "This DNA-testing-based evidence shows that while mixed-breed dogs are in fact less likely than purebreds to develop the recessive disorders evaluated in the study, they may still be carriers." The study examined the DNA of more than 100,000 dogs (18,000 purebreds representing 330 breeds, types, and varieties, and 83,000 mixed-breed dogs) for the presence of 152 genetic disease mutations, including: Progressive retinal atrophy (multiple forms) Hyperuricosuria Collie eye anomaly Multidrug sensitivity (MDR1) von Willebrand's disease (multiple forms) Based on the 152 diseases tested: Approximately two out of 100 mixed-breed dogs are at risk of becoming affected; 40 …
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