A Journey Through Canine Osteosarcoma

One veterinarian’s personal story.

Originally published in the January 2016 issue of Veterinary Practice News. Did you enjoy this article? Then subscribe today! 

My wife pointed out a slight swelling on the left distal radius of my beloved great Dane, and my heart sank instantly.

Canine osteosarcoma hit me very personally that day, July 22, 2014. Taylor Dane, as we named her, had come into our lives eight years earlier as a beautiful 7-month-old from Great Dane Rescue. Her original owners had relegated her to a lonely existence, isolated in their backyard. Having spent her early important socialization months isolated from new people and pets, she was terrified.

At first, we had to keep a house leash on her, even indoors, just to be able to get hold of her. But as her fear turned to trust, Taylor took over our house, and my heart.

I have had many dogs since childhood, dogs that I have loved dearly. But never had I experienced the depth of connection that I would have with Taylor. A tall and elegant fawn female, Taylor had a personality as big as her body. She was wonderfully exuberant, completely affectionate and very "large and in charge.”

She would stare into my eyes as if trying to memorize my face and communicate. This relationship was something special and it quickly grew deep, for both of us.

So imagine how it felt when the radiographs confirmed my worst fear; Taylor indeed had osteosarcoma and, without her showing a single sign of pain or lameness, the tumor had already encompassed three-fourths of the circumference of the radius.

At far left, radiograph shows the removed section of cancerous bone.

Jim Humphries, DVM

At far left, radiograph shows the removed section of cancerous bone.

We are fortunate to live near the Flint Cancer Center at Colorado State University, so I took Taylor there to discuss treatment options. After long discussions with several specialists, we decided to attempt a limb-sparing procedure.

On Aug. 1, 2014, the distal two-thirds of her diseased radius was removed and replaced with cadaver bone. An equine plate was used for fixation because even the longest canine plate was too short.

Taylor did very well with surgery, and as would be true throughout her many treatments, she handled everything we asked of her with quiet dignity. She would lie quietly for her twice-a-day bandage changes. She began chemotherapy, receiving four treatments of carboplatin three weeks apart.

She healed from surgery and learned to use her new leg. It helped tremendously that my wife is a physical therapist. She did Taylor’s bandage changes and daily physical therapy. Taylor took it all in stride and soon mastered running up and down the hills of our horse farm. She learned to climb up and down the stairs and even returned to jumping up to join us in bed, as much as we tried to prevent it.

Our girl was back, as happy and active as ever.

Because infection is the greatest problem with limb-spare cases, Taylor remained on high doses of antibiotics. Still, within months she began to show signs of infection in the lower leg.

Cultures revealed an MRSI infection and, even with targeted therapy, it eventually went to the bone and caused the fixation screws to lose purchase. We faced an agonizing decision.

We felt strongly that Taylor would not do well with a front leg amputation. She was an almost 9-year-old giant breed who lived on a hilly property, and we were greatly concerned that her remaining front leg would quickly begin to break down.

She also had two large, exuberant Dane buddies whose play was a constant challenge to her balance.

Dr. Jim Humphries says the term "human-animal bond" doesn't come close to describing the depth of his connection with Taylor Dane, his once-in-a-lifetime dog.

Jim Humphries, DVM

Dr. Jim Humphries says the term "human-animal bond" doesn't come close to describing the depth of his connection with Taylor Dane, his once-in-a-lifetime dog.

But we chose amputation, planning to fit her with a prosthesis.

The home post-op care of an amputation requires much time and commitment. With her gentle, cooperative spirit, Taylor went through endless bandage changes, learned to get up and down and walk on three legs.

Because she was so large, she wore a special harness to allow us to help her get to her feet. Our house sits at the top of a hill and the ground drops off on all sides; there is very little level ground. This produced great challenges to Taylor as she became accustomed to being a tripod. This was the roughest time, but after about three weeks, she was ready to fit for a prosthesis.

Taylor received her prosthesis March 12, 2015. She didn’t immediately use it, however. She would hold it in the air and stand and walk on three legs. It took twice-daily work over many weeks to teach Taylor how to first put weight on her prosthesis and then how to move in it.

It made such a difference when she learned simply to stand with weight on it. She could now stand comfortably and for as long as she wanted; no more trying to balance on three legs. She could also sit again now that she could put weight on both her front “legs.”

Below, radiographs of the leg post-limb-sparing surgery.

Jim Humphries, DVM

Below, radiographs of the leg post-limb-sparing surgery.

With a lot of patience and training, Taylor started going for walks around the property with her people and two Dane buddies. Eventually she was running up and down the hills and accompanying us on walks to the pond. She learned to ride in the golf cart and come up the steep deck stairs on her own.

Soon, she was going out in the mornings with her buddies and stayed out playing for an hour or more before coming up the stairs and greeting us with a happy, tired dog grin and a muddy, well-used prosthesis.

Taylor even returned to her habit of jumping in her bed and asking for bedtime back rubs, a habit that I admit I spoiled her into expecting. After the dogs would come in from their last go-out of the night, they would all run to their beds for biscuits.

Taylor would fly across the room on her prosthesis and jump and spin around on her bed. After receiving her biscuit, she would sit and look at me over her shoulder, asking for that back rub before she would lie down for the night.

The median survival rate for OSA is 12 months. This past July, we celebrated the 1-year anniversary of Taylor’s cancer survival. She returned to CSU for a check and everything looked very good. I was sure we caught it early and had given her the very best treatment possible. I was sure we had beaten this killer. I began to look toward the goal of Taylor turning 10 in April.

But in August, Taylor began occasionally crying in pain when rising. We instituted a multimodal pain program. She did well for a while, but the occasional pain returned and seemed worse.

She became slightly ataxic in her rear legs and started to lose tone in her right rear leg. The pain progressed to both with lying down and rising. She stopped sleeping on her side and slept only on her sternum.

Still, once up with her prosthesis on, Taylor was active, interactive and happy. She continued to seek us out often for attention, but was beginning to spend more time sleeping in her favorite spot on the deck, where she could overlook her property.

In the early morning hours of Sept. 10, she could not get comfortable. She got up to reposition to another bed and began to cry in pain. This cry was serious. Even with my wife’s help, she could not support herself; her hind legs simply would not work.

I will never forget the way Taylor looked at me, trying to stand on her own and crying. Those eyes that I had seen thousands of times when she would communicate love and affection now looked at me and very clearly said, “This is going to be hard on you and hard for me, but you must now let me go.”

It was as if she has spoken the words. And so, heartbroken, I did.

After sedation, and with our words in her ears and our tears falling on her face, she passed in our arms.

Below right, the distal breakout of infection that necessitated amputation.

Jim Humphries, DVM

Below right, the distal breakout of infection that necessitated amputation.

No more pain, Taylor.

I cannot describe the huge hole she left in our home and our hearts. This was my once-in-a-lifetime dog-human relationship, and it was over.

As I look back on the 14½ months of our fight against osteosarcoma, I wondered if I would do it all again. Would I put Taylor through two big surgeries, chemotherapy, the countless bandage changes and the struggles of learning to use her prosthesis?

Yes, I would do it all over again. I would not take anything for those great extra months.

The term “human-animal bond” can’t come close to describing the connection and love that develops between us and our wonderful pets.

I am grateful to have had an additional 14½ months with my Taylor Dane. I loved that dog deeply, and she loved me and trusted me without reserve. She had really good times in the months after diagnosis, and her bad times were few and short. She required a lot of our time, but we were happy to give it.

I am also very grateful to have had Taylor insured. With the many wonderful things we can accomplish with advances in veterinary medicine, pet health insurance is more important than ever.

Having insurance gave us options we could not have considered were she not insured.

My experience is not unique. Canine cancer is common, and each case is deeply personal.

Cadaver bone with plate in place in original limb-sparing surgery.

Jim Humphries, DVM

Cadaver bone with plate in place in original limb-sparing surgery.

Each case potentially steals not only a dog’s life, but it painfully ruptures that wonderful bond we have with those dogs who have so deeply inserted themselves into our hearts. 

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19 thoughts on “A Journey Through Canine Osteosarcoma

  1. Just got the news today about my 6yo Italian mastiff’s osteosarcoma diagnosis. So much to take in but I can’t stop crying. Not sure where to go from here but this story helps. Your description of this once in a lifetime dog-human Bond is on point. Thanks for sharing.

  2. Thank you for sharing your story. I can relate- my 9yo Fila will have a biopsy next week. She is limping and the x rays show a preliminary diagnosis of ostogenic sarcoma. She’s got the most precious eyes- the sweetest dog you could meet. I rescued her 5 years ago from the streets- lost, terrified, pregnant and extremely underweight. She quickly became the light of my eyes… we too have a special bond. your story helps and give a real perspective of what to expect.

  3. I got the news yesterday that my 8 year old Great Dane has osteosarcoma. She has been losing tone in her leg, she’s lethargic, and she’s not interested in food. The vet informed us that they found it is in her leg, chest, lungs, and ribs. He doesn’t believe she would survive surgery or chemo. I feel numb. I know what I need to do, but it hurts to think about. She’s in so much pain even though she’s on 2 different pain meds. I don’t want her to hurt anymore.

  4. I just now had to euthanize our 10 year old English Mastiff. We knew her time was getting short, but when a little stumble turned into a slight limp, we had no idea that just 3 days later she would be unable to bear weight on her leg, and our vet would confirm our worst fears. We chose not to treat, due to her age, but your story is still comforting–our Tinkerbell would not have tolerated the treatment as well as your Taylor Dane. She’always been emotionally debilitated by pain or illnesses. So your story helps us know we made the best choice today–thank you.

    1. Your comment about emotionally debilitated really hit home for us. Our lab mix was just diagnosed & we roe evaluating our options. But every time we think of surgery or chemo or radiation we think about how unhappy she will be. We re leaning towards not to treat too & hope it’s the right choice.

  5. We have an almost 9 year old chocolate Labrador who was diagnosed a week ago with osteosarcoma by X-rays. I love this boy so much and it’s killing me to have to make this decision for him. It began with a limp and swelling on his left front leg. We just thought it was a sprain. We quickly found out it was much more. The hardest part I’m dealing with is….who am I buying the time for? As much as I can’t imagine him not here with us….I also can’t imagine how the few months or so it might buy him be worth it. If it takes him 3 to 6 months to recoup from the amputation with treatment. Can he even pull through it? If so…how miserable will he be trying to fight? He’s the best fur baby we have owned and I’m the one who is having the hardest time with it. Hubby and kids are too! But i think the reality is I have to put his needs first. Right now he’s on pain meds….but the crazy thing besides the limp with swelling he has shown no signs of pain even before he began pain meds. I know in my heart it would not be fair to him to put him through that. He’s at home with us now and we are enjoying every moment we can get with him. As it progresses and we see pain….we will have him put down. I don’t want my last moments with him to be painful and I know he has lived a full life full of love and family. He will be cremated so we can bring him home. I think you have to decide for each individual family and fur baby what it in their best interest. Had they found this when Jake was younger….i would have chanced the surgery with chemo. But with him almost being 9 years and it may only buy him a few months to a year….it’s not a chance I’m willing to put him through. Because that would be for me and not him.

    1. We have a almost 10 year old shepherd hound dog the sweetest boy ever we also thought he sprained his front leg. But found out today he has osteosarcoma we are heart broken .We also are not going to put him through amputation or chemo just going to try to make him comfortable until it gets bad and then do what has to be done .I will miss him so much I love him so much my heart goes out to your jake my baby is. Ames jake to god bless

  6. Two days ago I lost my beautiful girl kassi, a Springer Spaniel. She had gone off her food and started limping but unlike these stories hers was her back leg. The vet thought it was a cruciate ligament injury and Friday was to go in for x rays. On Thursday evening I called her to bed (she slept on my bed) and she had only taken one step when she started screaming in agony I’ll never forget those screams. I immediately thought the ligament must have snapped. I slept on the couch with her next to me on the floor, covered with blankets.
    Next morning she managed to hobble on three legs moaning as she did so. She was taken straight into the back of vets and I left her awaiting the call to collect her later. The call came my baby’s leg was broken it had snapped and was too damaged for pins to be attached. Aggressive bone cancer the vet said amputation which would only be a short term solution before the cancer returned.
    I am broken hearted I had to say goodbye to my loyal faithful pal of 7 years and her screams are haunting me!

  7. My 12 year old black lab has been diagnosed with ostiosercoma at the moment still likes his walks but limps his left carpus has a lump on it he is on previcox 227 daily at 12 years wedont want amputation as we are told his life expectancy could be up to a year which would make him 13 while we feel he has quality of life we will keep him going but when we are keeping him going for our Benifit it will be time to let my solemate go

  8. I just found out my Newfoundland has osteosarcoma, we don’t have the money to do extensive chemo, etc, it too advanced, it’s killing me, he’s only 4. How you say goodbye to your best friend?

    1. I have a 10 year old Newf. Found out yesterday he has advanced Osteosarcoma. My eyes hurt from crying. He also is my best friend and our bond is similar to the bond I have with my kids. Im not sure how my life will be without him.

  9. Big sigh. Laying on the floor with my 11 year Dane, Amani who I have decided to put down this coming Friday 🙁 soul mate best friend, def a once in a lifetime animal partner. We still have good days but I fear I will get that look that your dog gave you. Hardest decision I’ve made this far in my life.

  10. I want to thank everyone for sharing your stories here- I am sorry for the sadness and pain, but I am grateful to know I am not alone in my grief over my English Mastff doggie soulmate Henry, who I got when he was 16 weeks old. And now he is 9, and had a lump just 2 weeks ago, and its growing so fast…. he has bad hips so amputation is not an option. Vet confirmed osteosarcoma yesterday… and I’m not sure my dog can make it another week… brokenhearted. He is the essence of pure love, friendship and joy… a true angel. The best part of me… that’s what he is. Like the author I have bonded with my prior dogs, both were precious to me, but Henry is so special..I am sad but I dont want him to be in pain anymore. I do believe dogs are in heaven and crazy or not, that makes me feel better. I wish all of you peace and comfort and thank you for sharing.

  11. One of mine, a Rhodesian Ridgeback 5 months shy of her 9th birthday, was diagnosed on September of 2017. By all accounts she’s beat the average survival rate at this point, but have made the decision to help her move on to a better life later this month. Breaks my heart to pieces but it is the most selfless thing I can do for her.

    Before she was diagnosed, she began limping (right, hind leg) and I thought it was caused by her rough play with my other RR. Such was not to be and instead we were given this grim result. We began immediately with a combination of Rx: Carprofen and Tramadol. To our surprise, she stopped limping after 4-6 weeks and she was even playing harder than before not long after that. We even stopped the Tramadol. The vet was simply amazed; we were just ecstatic and happy for her.

    Fast forward to January of this year, the limp came back with a vengance and we went back to adding Tramadol and Gabapentin. She’s pretty much now on 3 legs, barely putting weight on her left one.

    A few days ago she managed to go up the stairs in the house; I wish she hadn’t. Coming down was excruciating; a scream I wish no one experiences with their pup. If that was the case even with all the meds, I can just imagine the agony without them. This is not the life we want for her to experience.

    After that, we’ve made the decision, the toughest one we’ve had to make. We realize we need to do this for her, not for us.

    Deeply saddening, but comes with the territory, unfortunately.

  12. We too, were just diagnosed this morning with our dog having Osteosarcoma. Even though I knew it in my heart, I still broke when I got word. Our Sophie girl just celebrated her 10th birthday, pretty old for a Great Dane. I’ve considered every day passed her 8th birthday, “borrowed time”and a blessing. She began limping a few weeks ago on her front leg, and once the bump formed, I knew. The question is, do we just keep her comfortable with pain meds and anti inflammatories, or do we try radiation? Do I realized that 10 years is a good life span and just let go? Is it cruel to put her through radiation? So many unanswered questions and decisions to be made. We got her 1 month before we got pregnant with our first child. She was our, “can’t get pregnant after miscarrying the first baby, let’s get a dog”, dog. 8 months later, we got our baby girl. They have grown up together, which also makes this as heart retching as possible. No clue what to do. Just know my first baby girl, AKA Sophie was a one of a kind. She never understood her size. Lap dog all the way, sleeps with us in bed, backs up to the couch and sits down with us, just part of the family. I pray she makes the decision for us and goes on her own and we don’t have to make the call at all.

  13. My 10yr old boy was just diagnosed. I feel like my heart has shattered a hundred times in the last 36 hours. We’re going to amputate to alleviate his pain and hopefully have 5+ good months. It isn’t fair.

  14. Our Rotty….Rocky has recently diagnosed with an Osteosarcoma. We too thought he injured himself during rough play. We saw it when it happened so we were convinced it was not cancer…..until the limp never went away & eventually he would scream out in pain. It is the most awful helpless thing to watch. We don’t want to put him down, but we also dont want to continue seeing him in pain. He is such a gentle giant….best dog personality ever!!! I just dont know what to do. I am so torn 🙁

  15. I am still in shock trying to process the events this week. My pit bull mix has had hip displaysia for a couple of years and has been on a pain med & Dasuquin. She has been limping for over a month and we thought it was her arthritis and maybe she had pulled something while overcompensating for her hip displaysia. I had her at the vet a week ago for her limp and the vet said maybe an infection and gave her antibiotic but also did a biopsy of a lymph node. I called the Friday before Lanor day weekend and asked for xrays and they could not get to her until Tuesday after the holiday. I dropped her off and she was trembling, as usual and as always I had to trick her into going back with the vet asst by pretending that I am going along. I get a call later asking permission to sedate for x-ray because of her level of pain. Then I get the call that her bine is fractured from the cancer and it has also spread all through her body with many tumors in her lungs. It was recommended to euthanize her while she was still sedated. We immediately went to be with her but don’t know if she even knew we were there. I have never felt so helpless and heartbroken and keep questioning my hasty decision. I could not bear to think of her in such pain. I can’t breathe for crying. I have had dogs all my life but none like her. When I asked the vet why she would beg to go for walks if it was that painful & she said because our dog had so much heart. I am not sure how I will get through the days without her and am horrified that the last time she saw me was leaving her in a place where she was so frightened. I pray that she knew we were by her side loving her when she left this world.