Presentation A nine-year-old intact female Bulldog presents for lethargy and decreased appetite. On exam, the mucus membranes are tacky, and the abdomen is tense on palpation. Blood work identifies leukocytosis with neutrophilia, azotemia, and increased globulins. Photo courtesy Kendra Freeman Challenge 1) Risk factors for the development of pyometra include: a) Retriever breed b) Estrogen administration/exposure c) Increased age d) All of the above 2) The incidence of pyometra in intact females is: a) 15 percent b) 20 percent c) 25 percent d) 30 percent 3) The most common bacteria isolated from pyometra discharge is: a) E. coli b) Streptococcus sp. c) Staphylococcus sp. d) Klebsiella pneumoniae Reference Xavier RGC, Santana CH, de Castro YG, de Souza TGV, do Amarante VS, Santos RL, Silva ROS. Canine Pyometra: A Short Review of Current Advances. Animals (Basel). 2023 Oct 25;13(21)