Canine

New research for canine, human Type 1 diabetes holds promise

August 24, 2018

Reversing Type 1 diabetes in dogs and humans without the use of daily insulin injections or pumps may become a reality, thanks to a collaboration between Purdue University and the Indiana University School of Medicine. In a preclinical study, researchers developed a mixture of collagen and pancreatic cells and engineered a delivery method that successfully reversed Type 1 diabetes within 24 hours and maintained insulin independence for 90 days. A clinical study in dogs with naturally occurring Type 1 diabetes in collaboration with Purdue's College of Veterinary Medicine is next. "We plan to account for differences from mouse to human by helping dogs first," said Clarissa Hernandez Stephens, first author on the work and a graduate researcher at Purdue's Weldon School of Biomedical Engineering. "This way, the dogs can inform us on how well the treatment might work in humans." Because diabetes in dogs and humans occurs the same, both potentially could benefit from the same cure: A new set of pancreatic cells to replace islets (clusters of cells) that aren't releasing insulin to monitor blood glucose levels. Islet transplantation isn't new, and it poses challenges: It requires multiple donors, it's invasive, and large numbers of transplanted …

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NIH awards UF veterinarian five-year grant to study canine diabetes

August 24, 2018

Allison O'Kell, DVM, a small animal internal medicine specialist and clinical assistant professor at the University of Florida College of Veterinary Medicine, has received a Mentored Clinical Scientist Research Career Development Award from the National Institutes of Health in support of her studies relating to canine diabetes. The five-year grant, known as a K08, will support Dr. O'Kell's career and research project. "The overall goal of my research is to study the causes of diabetes in the dog," O'Kell said. "We hope that the work will benefit dogs with this disease, but also to help us better understand whether studying the disease in dogs may be a novel way to understand the disease in humans." The disease has been increasing in prevalence over time in both dogs and humans, emphasizing the importance of research to determine the underlying causes of the disease as well as methods for prevention and treatment, she added. O'Kell's primary mentor is Mark Atkinson, PhD, the American Diabetes Association Eminent Scholar for Diabetes Research and Jeffrey Keene Family Professor in the UF College of Medicine. Atkinson also directs the UF Diabetes Institute and has been investigating human Type 1 diabetes for …

Blue Buffalo Co. launches canine obesity, joint health diet

August 23, 2018

Blue Buffalo Co. has launched BLUE Natural Veterinary Diet W+M Weight Management + Mobility Support for dogs. According to the company, the therapeutic diet contains L-carnitine, which has been shown to facilitate weight loss and help maintain lean body mass in dogs; betaine, which supports dogs' ability to metabolize fat; moderate levels of dietary fiber from powdered cellulose, pea fiber, dried tomato pomace, and chicory root, which promote satiety and weight loss; turmeric, vitamin C, and vitamin E to limit oxidative stress, which has been found to be involved in the pathogenesis of osteoarthritis. It also contains EPA, DHA, glucosamine, and chondroitin sulfate, as well as deboned salmon, fish oil, canola oil, flaxseed, and shrimp meal.

FDA approves NexGard expanded label claims

August 22, 2018

Merial, part of Boehringer Ingelheim, received approval from the U.S Food and Drug Administration to expand the label claims for NexGard (afoxolaner). The flea and tick control product is now approved to prevent Borrelia burgdorferi infections as a direct result of it killing Ixodes scapularis vector ticks, commonly called black-legged, or deer, ticks. NexGard is the first and only flea and tick product to receive FDA approval for preventing infections that cause Lyme disease by killing the vector ticks, the company stated. The approval comes just as veterinarians and pet owners in many parts of the country are being warned about the potential of an increased number of Lyme disease cases in 2018. The FDA approval is based on two well-controlled laboratory studies that showed that NexGard effectively prevented the transmission of B. burgdorfei infections after dogs were infested with wild-caught I. scapularis ticks 28 days after treatment with NexGard, said the manufacturer. "Both studies measured the transmission of B. burgdorferi to dogs after exposure to infected ticks," said Zach Mills, DVM, head of US Pet Veterinary Professional Services. "All dogs treated with NexGard tested negative for B. burgdorferi infection, demonstrating that transmission was prevented as a direct result …

STAAR 2019 canine rehab, wellness conference registration open

August 21, 2018

The Symposium on Therapeutic Advances in Animal Rehabilitation (STAAR) has announced that registration is open for the April 24-28 event held in Florham Park, N.J. This lab-focused working conference is ideal for veterinarians, surgeons, veterinary technicians, physical and occupational therapists, and specialists treating functional impairments and working to prevent injury and maximize performance in canines, the organizers stated. "STAAR's unique method of education incorporates lecture with interactive practical labs designed to imprint and reinforce skills that can be implemented immediately into practice," said the conference hosts in a statement. "Instructors include many of the pioneers in the field of animal rehabilitation, as well as internationally recognized educators in canine physical therapy and sports medicine." Attendees can explore new concepts, advanced techniques, and the latest treatments in rehabilitative medicine and physical therapy while practicing skills on their target audience. Dogs are plentiful—usually one dog per three to four attendees—which allows ample practical opportunity and experience. Also, STAAR allows attendees to register only for the course(s) and the workshop(s) they want, rather than registering for an entire conference. Some of the workshop labs being offered at STAAR 2019: Myofascial manual therapies for the axial skeleton and extremities; Laurie Edge-Hughes, BScPT, …

Rocky Mountain spotted fever epidemic at US border, study says

August 21, 2018

A study published by the School of Veterinary Medicine at Universidad Autonoma de Baja California and the University of California, Davis says ticks are causing a deadly Rocky Mountain spotted fever (RMSF) epidemic in Mexico, and health officials are concerned it could spread to the U.S. Dr. Luis Tinoco-Gracia, a research professor in the School of Veterinary Medicine at Universidad Autonoma de Baja California and director of the Laboratory of Veterinary Public Health Sciences, in Mexicali, Mexico, and colleagues from the University of California, Davis published the report in the September 2018 issue of Emerging Infectious Diseases, the Centers for Disease Control and Prevention's public health journal. The RMSF epidemic began in 2008 in Mexicali, adjacent to the U.S. border in Baja California. In 2014, a fatal human case was reported in Imperial County, Calif. In 2015, the Mexican Ministry of Health declared an epidemiologic emergency, which as of 2018 has affected approximately 4,000 people. Since that time, four people who have been carrying the disease and crossed the border to the U.S. have died. Overall, since 2000, the incidence of RMSF in the U.S. has increased markedly, the study authors said. "Overall, since 2000, in …

Client checklist: Controlling canine influenza virus

August 10, 2018

With summer underway, plenty of dogs are enjoying fun in the sun with their canine companions, play-fighting and sharing water bowls. Of course, accompanying summer vacation is the increased risk of infectious diseases and other illness. Canine influenza virus (CIV) is at an all-time high this year, with reported cases in at least 46 states. As such, it is more important than ever for veterinarians to warn their clients of some of the tell-tale signs of the illness. Here are some suggestions for helping clients protect their pets from illness year-round, courtesy of Zoetis. Identifying clinical signs Symptoms of CIV are similar to those of other bacterial and viral causes associated with Canine Infectious Respiratory Disease (CIRD). Much like humans, signs of the virus often vary from dog to dog and can last for several weeks. Some symptoms to look out for include: Reduced appetite High fever Cough Runny nose Lethargy Additionally, CIV has no seasonality, so owners should keep an eye out for these symptoms throughout the year; however, it is especially important to keep watch during the summer when dogs tend to spend more time outdoors, socializing with other dogs. Considering treatment options If an owner suspects …

WSAVA-endorsed paper encourages healthier breeding

August 6, 2018

The World Small Animal Veterinary Association (WSAVA) has announced its support of a position paper launched in June 2018 by the Federation of Veterinarians of Europe (FVE) and the Federation of European Companion Animal Veterinary Associations (FECAVA). The paper, a response to the explosion in popularity of breeds with exaggerated traits, genetic disorders, and those with extreme brachycephalic conformation, such as French and English bulldogs and pugs, calls for health and welfare to be given priority over looks and offers detailed recommendations to address increased demand for and supply of these dogs. Measures to reduce demand, supply Address demand for brachycephalic and other affected breeds through educating owners about the health issues they face Work with influencers to encourage owners to choose a healthy, high-welfare dog suitable for their lifestyle Introduce the mandatory registration of breeders, prebreeding screening programs, and the sharing of data on conformation-altering surgeries and caesarean sections Educate stakeholders and revising breeding standards and practices to put the health and welfare of dogs first In addition, FVE and FECAVA have produced an infographic that explains the causes and consequences of extreme breeding and lists a number of …

Morris Animal Foundation announces second National Dog Day campaign

August 3, 2018

Since 2004, National Dog Day has been observed on Aug. 26 to encourage dog ownership of mixed-breed and purebred dogs, and to remind us all that canine companions deserve to live long, healthy lives. That's why for the second year in a row, Morris Animal Foundation (MAF) is running a campaign this month through Aug. 26, in which an anonymous donor will match all gifts made to the Golden Retriever Lifetime Study, dollar for dollar, up to $50,000. The $32 million study gathers information on more than 3,000 golden retrievers throughout their lives to identify the nutritional, environmental, lifestyle, and genetic risk factors for cancer and other canine diseases. Its primary goal is to reveal potential risk factors that may lead to the development of four types of cancers common in golden retrievers: hemangiosarcoma, mast cell tumors, lymphoma, and osteosarcoma. Donations can be made to the Golden Retriever Lifetime Study at MAF's website here.

ELIAS presents preliminary canine osteosarcoma results at ACVIM