Elanco, FDA Say Trifexis Played No Role in Dog DeathsAugust 5, 2014 Trifexis, a flea killer and heartworm preventive introduced in 2011, is being blamed for nearly 1,000 dog deaths, but both the manufacturer and the U.S. Food and Drug Administration cautioned that no evidence has been found tying the drug to the claims. Atlanta television station WSB learned after filing a Freedom of Information Act request that the FDA had received 965 complaints of Trifexis-related dog deaths. Pet owners have debated the drug’s safety on multiple websites and even started a Facebook page called Does Trifexis Kill Dogs? FDA, which approves and regulates human and animal drugs, acknowledged that dog owners and veterinarians have lodged formal complaints about Trifexis (spinosad and milbemycin oxime). “FDA is aware of adverse event reports in connection with Trifexis and continues to closely monitor them,” the agency reported in a prepared statement. “It is very important to realize that reports of adverse events do not necessarily mean that the product caused the event. Other factors, such as existing disease, exposure to chemicals or contaminants, foods, or other medications may have triggered or contributed to the cause of the event.” WSB-TV also reported in late July that 1,500 Trifexis complaints were …
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CAPC Urges Additional Heartworm TestsAugust 4, 2014 The Companion Animal Parasite Council (CAPC) has updated its heartworm guidelines to recommend that a microfilariae test be performed annually on all dogs in addition to the customary antigen test and that veterinarians consider administering tests twice a year in heartworm-prevalent areas. Reports of an increasing number of false-negative antigen results led the Salem, Ore., organization to modify the guidelines July 28 after a meeting of the American Association of Veterinary Parasitologists. Some dogs appeared to have developed immune complexes that led to a rising number of false negatives involving commercial antigen tests. “Some of the CAPC parasitology specialists speculate that one of the reasons for the increase in these false-negative test results may be related to the practice of placing heartworm-infected dogs on long-term regimens of macrocyclic lactone preventives and antibiotics rather than treating them with an approved adulticide,” the organization stated. The combination treatment, known as the slow-kill method, came into favor with some veterinarians because of an ongoing shortage of Immiticide, an adulticide manufactured by Merial Ltd. Dogs managed with these protocols may experience prolonged inflammation, which could result in the formation of immune complexes that mask the detection …
Liposuction For Pets: Procedure Becoming Increasingly PopularJuly 31, 2014 Follow Veterinary Practice News on Twitter at @vetpetnews. Our society is a bit obsessed with appearance. Countless ads pop up on radio, television and in magazines promoting breast augmentations, anti-aging creams and countless ways to lose weight (through exercise, weight-loss programs, special diets, medications and surgeries). One such option is liposuction. The ad may show a woman with a not-so-flat belly next to a picture of one with a toned stomach, telling people that liposuction was the answer. So when I saw in the news that liposuction was now available for pets, I thought our society had gone too far. But, like everything else, you have to read the fine print. Although referred to as liposuction, when the procedure is performed on pets it is not cosmetic (even if your client’s pet is hoping for a svelte figure). It’s actually used to improve the health of the pet. The non-invasive procedure removes the fat from lipomas in overweight and senior dogs. If gone untreated, they can grow quite large and impede the dog’s movement. “They can be really big,” Rebecca Pentecost, DVM, told Fox 8 Cleveland. …
Avivagen Explores Possible Breakthrough in Female SterilizationJuly 30, 2014 A Canadian animal health company wants to do for female dogs and cats what Ark Sciences Inc. is doing for male dogs. Ark Sciences this year began shipping to veterinarians an FDA-approved nonsurgical sterilization drug, Zeuterin Injectable Solution, that is formulated to permanently cease canine sperm production. Seizing an opportunity on the female side, Avivagen Inc. of Ottawa, Ontario, is partnering with University of Saskatchewan veterinarian Duncan Hockley, DVM, who invented what the company calls a drug-based alternative to surgical spaying. The agreement puts Avivagen first in line for an exclusive license to a technology designed for the permanent sterilization of female mammals, starting with dogs and cats and potentially extending to livestock, wild animals and even humans. The technology, which for now goes by the name “Sterilis Project,” is a long way from hitting the veterinary market. Avivagen hopes to finish proof-of-concept work by year’s end and at some point launch trial studies. “We estimate that a nonresource-constrained project could attain registration in about five years, absent technical hurdles and delays in reviews,” said Avivagen’s CEO and president, Cameron Groome. How the “Sterilis Project” drug would work on females is …
Humane Alliance Spay/Neuter School ExpandsJuly 30, 2014 A clinic designed to teach spay and neuter procedures to hundreds of veterinarians and fourth-year veterinary students each year opened Tuesday in Asheville, N.C. The Humane Alliance Spay/Neuter Training Center, which was funded through a $1.5 million grant from PetSmart Charities, features six surgical bays and enough kennels to accommodate 140 feline and canine patients. The host, Humane Alliance, is a nonprofit organization dedicated to teaching high-volume, low-cost sterilization techniques. “The support of PetSmart Charities allows us to increase the number of veterinarians who will take back new skills to their community to save more pets and make an impact nationwide,” said Quita Mazzina, executive director of Humane Alliance. The 12,400-square-foot training center includes office space for 16 staff members. A separate, 2,200-square-foot dormitory houses up to 20 students. PetSmart Charities, the charitable arm of the Phoenix-based PetSmart chain, has given more than $4.5 million to Humane Alliance since 2010. “When organizations come together and collaborate as we’ve done with Humane Alliance, the results can be transformational,” said Julie White, the charity’s senior director of programs, grants and field initiatives. Humane Alliance has helped create a network of 137 low-cost
3-Year Nonadjuvanted Rabies Vaccine Available for CatsJuly 29, 2014 Merial Ltd. has released what the Duluth, Ga., drug maker is calling the world’s first nonadjuvanted feline rabies vaccine with a three-year lifespan. Other three-year rabies vaccines are made with an adjuvant that increases a cat’s immune response but that has been blamed for causing vaccine-related fibrosarcoma, a rare disease. The new vaccine is part of the PureVax family, which includes a one-year nonadjuvanted rabies vaccine. “The recombinant technology that has also been used to produce other vaccines such as the one-year PureVax rabies … allows the development of effective vaccines for feline viral diseases without the need for adjuvants,” said Leigh O’Mara, Ph.D., PMP, an associate director of technical marketing for Merial. The three-year duration of immunity makes the vaccine a good choice for cat owners who don’t schedule regular veterinary checkups, Merial stated. “Veterinarians now no longer have to choose between a multiyear adjuvanted rabies vaccine and an annual nonadjuvanted rabies vaccine for clients who do not reliably return to the clinic annually,” the company reported Monday. PureVax Feline Rabies is recommended for healthy cats 12 weeks or older. A one-year booster vaccination is required after the initial shot. Rabies …
How Pain Management In Small Animals Has GrownJuly 29, 2014For Duncan X. Lascelles, a professor of small animal surgery at North Carolina State University College of Veterinary Medicine, understanding pain is the cornerstone to building a better foundation for treating it in small animals. And Lascelles, BVSc, Ph.D., Dipl. ACVS and ECVS, is encouraged by the improvements in recognizing pain being made in veterinary medicine and at institutions like NC State. "I think the first breakthrough I see is the increasing amount of information regarding pain assessment," Lascelles said. "We're seeing more tools for practitioners and also for clinical researchers." Better assessment tools enable practitioners to know whether non-drug therapies are working, and they enable practitioners dealing with pain management to better monitor the efficacy of their treatments Lascelles suggested that practitioners dealing with perioperative pain in dogs use the Glasgow Composite Measure Pain Scale Short Form. The same group that came out with the scale is soon to publish the feline version, Lascelles noted. For chronic pain in dogs, Lascelles likes the University of Pennsylvania's Canine Brief Pain Inventory and the Helsinki Chronic Pain Index. There are also a number of new tools that can help pet owners measure chronic pain, or can assist veterinary technicians with measuring …
Abbott Wins Approval of Daily Feline Pain DrugJuly 28, 2014 Simbadol, a pain-control drug designed to minimize the need for overnight dosing after feline surgery, has received approval from the U.S. Food and Drug Administration, Abbott Animal Health reported today. The medication is the first and only FDA-approved opioid analgesic for cats to provide 24-hour pain control in a single dose, the Abbott Park, Ill., drug maker noted. Simbadol (buprenorphine injection) is indicated for the control of postoperative pain associated with surgical procedures in cats. The drug has the backing of pain specialist Robin Downing, DVM, CVPP, CCRP, Dipl. AAPM, the hospital director at Windsor Veterinary Clinic and The Downing Center for Animal Pain Management in Windsor, Colo. “For the first time veterinarians have a once-daily opioid to provide 24-hour surgical pain control for their feline patients, even through the night,” Dr. Downing said. A randomized blinded clinical program involving more than 200 cats found Simbadol to be safe and effective, she said. Simbadol’s approval was the second this year for an Abbott veterinary drug. The FDA in February approved Paccal Vet-CA1 (paclitaxel for injection), which is indicted for the treatment of canine mammary carcinoma and squamous cell carcinoma. Abbott obtained the …
Apoquel Shortage Should End by April 2015July 27, 2014Update, January 2016: More Apoquel on Way for Dogs, Zoetis Says Dog owners desperate to put their pets on the new anti-itch drug Apoquel will have to wait nine more months as the manufacturer ramps up production. Zoetis Inc. of Florham Park, N.J., had expected the Apoquel shortage to last until mid-2015, but the company recently reported that the distribution clampdown should loosen sooner―by April 2015. Apoquel (oclacitinib tablet) received an enthusiastic response from dog owners and veterinarians after the drug hit the U.S. market Jan. 20. Often effective within 24 hours of initial use, the prescription-only drug is indicated for the control of itching associated with allergic dermatitis and the control of clinical manifestations of atopic dermatitis. The tablets, which work by blocking a dog’s urge to scratch, are given twice a day for the first two weeks and daily thereafter. The drug’s success combined with growing demand and a complicated manufacturing process quickly left Apoquel in short supply. Zoetis responded by giving priority to pets already on the drug and by rejecting new orders from veterinarians. In some cases, veterinarians who were able to get Apoquel were suddenly cut off. Steven …
AVMA House of Delegates Backs New Dentistry, Declawing PoliciesJuly 25, 2014 The American Veterinary Medical Association’s House of Delegates today approved revised policies on veterinary dentistry and cat declawing and chose the organization’s 2015-16 president. Meeting in Denver at the annual AVMA convention, the delegates followed the lead of the American Animal Hospital Association in advocating the use of anesthesia when dental procedures beyond an oral examination are performed. AAHA in June 2013 passed a rule requiring member hospitals to anesthetize and intubate all dental patients under the group’s updated Dental Care Guidelines for Dogs and Cats. Kate Knudson, DVM, the past president of AAHA and an alternate delegate, urged the House to pass Resolution 6. “The only way you can provide dental diagnostics and come up with a therapeutic plan is to do dental radiography,” Dr. Knudson said. “We have many, many, many studies … demonstrating how something that looks normal when you’re just looking at it with your eyes is abnormal once you take radiographs. “The only way you can look your client in the eye and give them the confidence that you indeed are giving the best therapeutic and diagnostic plan is to take full-mouth X-rays,” she added. “As of this time …
