New research for canine, human Type 1 diabetes holds promiseAugust 24, 2018Reversing Type 1 diabetes in dogs and humans without the use of daily insulin injections or pumps may become a reality, thanks to a collaboration between Purdue University and the Indiana University School of Medicine. In a preclinical study, researchers developed a mixture of collagen and pancreatic cells and engineered a delivery method that successfully reversed Type 1 diabetes within 24 hours and maintained insulin independence for 90 days. A clinical study in dogs with naturally occurring Type 1 diabetes in collaboration with Purdue's College of Veterinary Medicine is next. "We plan to account for differences from mouse to human by helping dogs first," said Clarissa Hernandez Stephens, first author on the work and a graduate researcher at Purdue's Weldon School of Biomedical Engineering. "This way, the dogs can inform us on how well the treatment might work in humans." Because diabetes in dogs and humans occurs the same, both potentially could benefit from the same cure: A new set of pancreatic cells to replace islets (clusters of cells) that aren't releasing insulin to monitor blood glucose levels. Islet transplantation isn't new, and it poses challenges: It requires multiple donors, it's invasive, and large numbers of transplanted …
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NIH awards UF veterinarian five-year grant to study canine diabetesAugust 24, 2018Allison O'Kell, DVM, a small animal internal medicine specialist and clinical assistant professor at the University of Florida College of Veterinary Medicine, has received a Mentored Clinical Scientist Research Career Development Award from the National Institutes of Health in support of her studies relating to canine diabetes. The five-year grant, known as a K08, will support Dr. O'Kell's career and research project. "The overall goal of my research is to study the causes of diabetes in the dog," O'Kell said. "We hope that the work will benefit dogs with this disease, but also to help us better understand whether studying the disease in dogs may be a novel way to understand the disease in humans." The disease has been increasing in prevalence over time in both dogs and humans, emphasizing the importance of research to determine the underlying causes of the disease as well as methods for prevention and treatment, she added. O'Kell's primary mentor is Mark Atkinson, PhD, the American Diabetes Association Eminent Scholar for Diabetes Research and Jeffrey Keene Family Professor in the UF College of Medicine. Atkinson also directs the UF Diabetes Institute and has been investigating human Type 1 diabetes for …
The skinny on pet supplementsAugust 23, 2018While certain supplements can have a place in joint disease management, some veterinarians are concerned about how they might be perceived by pet owners.
Increasing geriatric pet visitsAugust 23, 2018In the first two parts of this series, I discussed the staggering number of geriatric pets not visiting their primary care clinic and offered suggestions to help families caring for these animals—but how do we go about getting these grey muzzles into door so that we can help them?
Blue Buffalo Co. launches canine obesity, joint health dietAugust 23, 2018Blue Buffalo Co. has launched BLUE Natural Veterinary Diet W+M Weight Management + Mobility Support for dogs. According to the company, the therapeutic diet contains L-carnitine, which has been shown to facilitate weight loss and help maintain lean body mass in dogs; betaine, which supports dogs' ability to metabolize fat; moderate levels of dietary fiber from powdered cellulose, pea fiber, dried tomato pomace, and chicory root, which promote satiety and weight loss; turmeric, vitamin C, and vitamin E to limit oxidative stress, which has been found to be involved in the pathogenesis of osteoarthritis. It also contains EPA, DHA, glucosamine, and chondroitin sulfate, as well as deboned salmon, fish oil, canola oil, flaxseed, and shrimp meal.
Confronting the obesity epidemicAugust 22, 2018Pet obesity is on the rise, although really, that probably isn’t a surprise to most veterinarians since the number of conference sessions, scientific studies, and therapeutic diets addressing this issue are increasing exponentially.
UC Davis veterinarian discovers rare blood disorder in catAugust 22, 2018Miao Miao, a four-year-old male domestic shorthair cat, was brought to the University of California, Davis veterinary hospital with persistent nosebleeds. Based on previous medical issues, his owners were aware that he had some variation of a blood platelet disorder, but the exact makeup of that was never discovered. Specialists with UC Davis' internal medicine service ran a range of tests to discover the root of his bleeding issue. A complete blood count showed that Miao Miao was not anemic, had no evidence of inflammation, and a normal platelet count. An ultrasound also was performed, which showed that Miao Miao had no evidence of bleeding into any of his other bodily cavities. Miao Miao was hospitalized for a few days to ensure he did not develop significant bleeding, and so that the team could discuss his case with other clinicians and researchers. Through a collaboration of UC Davis emergency, internal medicine, and research specialists, a unique cause to Miao Miao's bleeding was found. Ronald Li, DVM, MVetMed, PhD, DACVECC, a critical care specialist with the UC Davis veterinary hospital's emergency room, operates a platelet physiology laboratory with equipment and capabilities found in only a handful of veterinary centers around …
FDA approves NexGard expanded label claimsAugust 22, 2018Merial, part of Boehringer Ingelheim, received approval from the U.S Food and Drug Administration to expand the label claims for NexGard (afoxolaner). The flea and tick control product is now approved to prevent Borrelia burgdorferi infections as a direct result of it killing Ixodes scapularis vector ticks, commonly called black-legged, or deer, ticks. NexGard is the first and only flea and tick product to receive FDA approval for preventing infections that cause Lyme disease by killing the vector ticks, the company stated. The approval comes just as veterinarians and pet owners in many parts of the country are being warned about the potential of an increased number of Lyme disease cases in 2018. The FDA approval is based on two well-controlled laboratory studies that showed that NexGard effectively prevented the transmission of B. burgdorfei infections after dogs were infested with wild-caught I. scapularis ticks 28 days after treatment with NexGard, said the manufacturer. "Both studies measured the transmission of B. burgdorferi to dogs after exposure to infected ticks," said Zach Mills, DVM, head of US Pet Veterinary Professional Services. "All dogs treated with NexGard tested negative for B. burgdorferi infection, demonstrating that transmission was prevented as a direct result …
STAAR 2019 canine rehab, wellness conference registration openAugust 21, 2018The Symposium on Therapeutic Advances in Animal Rehabilitation (STAAR) has announced that registration is open for the April 24-28 event held in Florham Park, N.J. This lab-focused working conference is ideal for veterinarians, surgeons, veterinary technicians, physical and occupational therapists, and specialists treating functional impairments and working to prevent injury and maximize performance in canines, the organizers stated. "STAAR's unique method of education incorporates lecture with interactive practical labs designed to imprint and reinforce skills that can be implemented immediately into practice," said the conference hosts in a statement. "Instructors include many of the pioneers in the field of animal rehabilitation, as well as internationally recognized educators in canine physical therapy and sports medicine." Attendees can explore new concepts, advanced techniques, and the latest treatments in rehabilitative medicine and physical therapy while practicing skills on their target audience. Dogs are plentiful—usually one dog per three to four attendees—which allows ample practical opportunity and experience. Also, STAAR allows attendees to register only for the course(s) and the workshop(s) they want, rather than registering for an entire conference. Some of the workshop labs being offered at STAAR 2019: Myofascial manual therapies for the axial skeleton and extremities; Laurie Edge-Hughes, BScPT, …
Rethinking euthanasiaAugust 21, 2018As veterinarians, we need to rethink what a meaningful and spiritual honor it truly is for us to oversee and minister compassionate euthanasia services for beloved pets.
